High mpv normal platelet count how to#
High mpv normal platelet count free#

So in this study, we aimed to investigate whether peroral iron treatment is associated with high MPV. Iron therapy should be given in caution to patients with thrombosis, heart disease, ischemic stroke. While iron therapy corrects thrombocytosis and normalizes peripheral thrombocytes it may also lead to release of large thrombocytes into peripheral blood.

During iron treatment bone marrow production of megakaryocytes can be induced leading to young and large platelets being released into peripheral blood. Small thrombocytes lead to thrombocytosis that occurs in IDA due to not be suppressed megakaryopoiesis.

Iron not only induces erythropoiesis but also suppresses megakaryopoiesis. Previous studies demonstrated MPV to be associated with both arterial and venous diseases. , Thrombocytes secrete many important substances such as coagulation, inflammation, thrombosis, and atherosclerosis mediators that increase the risk of occlusive vascular disease. They aggregate more rapidly with collagen and express more glycoprotein Ib and IIb/IIIa receptors. When compared to small thrombocytes large ones have more granules and a higher thromboxane A 2 level. MPV follow-up can be performed by using a low-cost routine hematologic test. It is an important marker of thrombocyte function. The mean platelet volume (MPV) reflects thrombocyte size. Excess iron in the body may be dependent on the HFE gene on chromosome 6 as well as it may occur with unnecessary or long-term treatment of iron.

High mpv normal platelet count free#

While iron deficiency leads to anemia its excess leads to both deposition of iron in the tissues as hemosiderosis and cellular damage by oxygen radicals as a result of the combination of free iron with peroxides radicals. It has been estimated that 30% of the world population suffers from IDA and most of them live in the developing countries.

Iron deficiency anemia (IDA) occurs due to increased body requirements, insufficient iron supply (depending on dietary iron intake and duodenal absorption) and blood losses. Serum ferritin levels are closely correlated with total body iron stores. If it is not used in erythropoiesis it is stored as ferritin or hemosiderin. It is the basic element for the production of new red blood cells (RBC). Iron is an essential trace element presents in a number of molecular systems and it is increasingly recognized as an important cofactor for a variety of cell systems. Evaluation of mean platelet volume before and after iron deficiency anemia treatment

High mpv normal platelet count how to#

How to cite this URL: Yuce S, Cure MC, Cure E, Kiztanir S, Yazici T. How to cite this article: Yuce S, Cure MC, Cure E, Kiztanir S, Yazici T. Keywords: Iron, iron deficiency anemia, mean platelet volume, thrombocytosis, thrombosis Even though thrombosis is corrected during iron treatment, the therapy increases the release of large and active thrombocytes into the peripheral blood. Conclusion: There may be an increase in thrombotic events due to hypercoagulability related to microthrombosis during IDA. The levels of ferritin ( P < 0.001), MPV ( P < 0.001), MCV ( P < 0.001), and Hb ( P < 0.001) were significantly higher in the posttreatment group compared to the pretreatment group. The mean ferritin level of the posttreatment group was 40.3 ± 15.2 ng/mL, MPV was 8.6 ± 2.0 fL, Hb was 12.5 ± 6.6 g/dL, and MCV was 77.6 ± 5.4 fL. Results: the mean ferritin level of the pretreatment group was 6.5 ± 4.0 ng/mL, MPV was 7.9 ± 1.5 fL, hemoglobin (Hb) was 9.8 ± 1.5 g/dL and the mean cellular volume (MCV) was 71.2 ± 7.2 fL. We evaluated retrospectively the hematologic and biochemical parameters prior to and 1 month after iron treatment. Daily ferrous sulfate (270 mg iron II sulfate and 80 mg of elemental iron) was given orally to patients. IDA was defined as ferritin level <50 ng/mL with a transferrin saturation <20% or ferritin <15 ng/mL.

Materials and Methods: A total of 80 patients (10 males and 70 females) with IDA were included in this retrospective study. Mean platelet volume (MPV) was measured as an indicator for the presence of these platelets. In this study, we investigated whether young, active, and large platelets are released into peripheral blood during iron treatment. Background: Iron inhibits megakaryopoiesis so iron deficiency anemia (IDA) leads to microthrombosis.